X-Chromosome Inactivation: A New Hope for Genetic Disorders

May 7, 2025

X-chromosome inactivation (XCI) is a fascinating biological process by which one of the two X chromosomes in female mammals is rendered non-functional to ensure that gene dosage remains balanced with males, who possess a single X chromosome.This complex mechanism plays a crucial role in the regulation of genes linked to X-linked diseases, such as Fragile X Syndrome and Rett Syndrome, both of which can have profound effects on development and cognition.
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X Chromosome Inactivation Treatments For Genetic Diseases

April 7, 2025

X chromosome inactivation treatments are at the forefront of innovative approaches aimed at tackling genetic disorders linked to the X chromosome, such as Fragile X Syndrome and Rett Syndrome.For females, the presence of two X chromosomes necessitates a mechanism to prevent the overexpression of X-linked genes, leading to the inactivation of one chromosome.
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